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Category:Hrvatsko Dubrovačko-njemačkog Akademija mladihDetermination of pharmacokinetics of paclitaxel by an HPLC assay on plasma and tumour tissue in experimental rabbits bearing human tumours.
The pharmacokinetics of paclitaxel (Taxol; Bristol-Myers Squibb, USA) were studied in rabbits bearing Ehrlich ascites tumours and Kaposi's sarcoma tumours after an intravenous bolus injection of paclitaxel at 12 mg/kg over 5 minutes, with sampling of blood, plasma, tumour tissue and tumour-free organs. Blood samples were analysed by high-performance liquid chromatography (HPLC) with a fluorescence detector. Pharmacokinetic values were obtained by a two-compartment open model with non-compartmental analysis (NCA). A linear relationship was obtained between concentrations and times, with a correlation coefficient of 0 be359ba680
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